SR 11302

Research use only, not for human use.

SR 11302 is an inhibitor of activator protein-1 (AP-1).

SR 11302 is an inhibitor of activator protein-1 (AP-1).(In Vitro):SR 11302 can inhibit the growth of breast cancer cell line T-47D, the lung cancer line Calu-6, and HeLa cells. SR 11302 had very little effect on either the proliferation or the differentiation of HL-60, fresh APL, and NB4 cells.(In Vivo):In an AP-1-luciferase transgenic mouse carcinogenesis model, SR11302 significantly inhibits both AP-1 activations in 7,12-dimethyl benz(a)anthracene-initiated mouse skin and 12-O-tetradecanoylphorbol-13-acetate-induced papilloma formation.

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Cell Cycle/DNA Damage

DNA/RNA Synthesis

11β-HSD1;Gap Junction Protein

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160162-42-5

376.5

C26H32O2

>98% (HPLC)

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CC(C=CC=C(C=CC1=C(C)CCCC1(C)C)c1ccc(C)cc1)=CC(O)=O

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(-20℃)

With Ice Pack

≥ 2 years